Tissue clearing with the SCALEVIEW-A2 solution has opened up new possibilities for deep imaging. When coupled with SCALEVIEW-A2 clearing, Olympus SCALEVIEW immersion objectives now allow researchers to reconstruct vast tissue areas at high resolution with the FV1200MPE system.
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Go Deeper with Award-Winning SCALEVIEW Microscope Optics


SCALEVIEW objectives, which have received multiple honors this year, help facilitate breakthrough research on the functioning of the brain and other vital organs. Until recently, brain science researchers using light microscopes had to slice thin sections of tissue. Every cut damaged and potentially deformed the samples, and the tissue itself was so opaque that it scattered most light. But with the new objectives, researchers can see up to 8 mm deep without slicing. This allows them to see the tangled, complex interconnectedness of the brain much more clearly. Having a better understanding the brain’s functioning could ultimately help sufferers with Parkinson’s, autism, Alzheimer’s, traumatic injuries and more.

The new objectives work so well because they were specifically designed and engineered for use with a revolutionary clearing reagent developed by Dr. Atsushi Miyawaki and his team at the RIKEN Brain Science Institute in Japan (results published online in Nature Neuroscience: Hama et al. Aug 30, 2011). Using the objectives and reagent together, tissue is made nearly transparent; scientists can now see the interconnectedness in brain and other tissues as never before.

Gold Edison Award

Olympus SCALEVIEW microscope optics was awarded the prestigious Gold Edison Award in the Science/Medical category. The internationally known Edison Awards honor the best in innovation and excellence in the development of new products and services.

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R&D 100 Award

Recognized as among the 100 most technologically significant products introduced last year, the Olympus SCALEVIEW 4 mm and 8 mm microscope objectives have earned the prestigious 2012 R&D 100 Award.

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Microscopy Today Top 10 Innovation Award

The Olympus 4 mm and 8 mm SCALEVIEW microscope objectives were judged among the year’s ten best microscopy innovations in the 2012 Microscopy Today Innovation Award competition.

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SCALEVIEW Immersion 25X Objective for Multiphoton

Specially designed to deliver optimum performance with SCALEVIEW immersion, this dedicated multiphoton objective with an ultra-long working distance enables high-precision imaging of tansparent-rendered biological specimens to a depth of 4 mm.

24 tiled areas composed of nearly
9000 images stitched together using
FluoView stage control and stitching
software, 4mm SCALEVIEW
Single Z-stack
acquisition with 4mm
Single Z-stack
acquisition with
Image data courtesy of:
Hiroshi Hama, Hiroshi Kurokawa, Atsushi Miyawaki
Laboratory for Cell Function Dynamics, RIKEN Brain Science Institute
Reference material:
Hiroshi Hama, Hiroshi Kurokawa, Hiroyuki Kawano, Ryoko Ando,
Tomomi Shimogori, Hisayori Noda, Kiyoko Fukami,
Asako Sakaue-Sawano & Atsushi Miyawaki
"Scale: a chemical approach for fluorescence imaging and reconstruction of
transparent mouse brain," Nature Neuroscience, advance online publication, 30 August 2011 (doi:10.1038/nn.2928)

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