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LV200 Bioluminescence Microscope

Bioluminescence imaging has been used in a range of research fields over the past decades. Despite its advantages of very low background, high S/N ratios and an extended linear detection range, luminescence imaging with traditional microscopes has suffered from low image resolution and long exposure times. These drawbacks have limited its use and kept bioluminescence in the shadow of fluorescence imaging. With its unique optical design, the LV200 microscope takes full advantage of bioluminescence and provides the capability to acquire images with unrivalled brightness, high resolution and convenience.
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Bioluminescence Reagents

Promega: NanoLuc™ Luciferase

List of Publications


  1. Saini C et. al., Simulated body temperature rhythms reveal the phase-shifting behavior and plasticity of mammalian circadian oscillators. Genes Dev. (2012) 26: 56-580.
  2. Jihwan Myung et.al., Period Coding of Bmal1 Oscillators in the Suprachiasmatic Nucleus. J Neurosci (2012) 32(26): 8900-8918.
  3. Bolinger T et. al.,Circadian Clocks in Mouse and Human CD4+ T Cells. PLoS ONE (2011) 6:12.
  4. Sramek C et al., Non-damaging retinal phototherapy: dynamic range of heat shock protein expression. Invest Ophthalmol Vis Sci. (2011) 52(3):1780-7.
  5. Fukuda H et al., Quantitative analysis of phase wave of gene expression in the mammalian central circadian clock network. PLoS One (2011) 6(8): e23568.
  6. Kowalska E et. al., The circadian clock starts ticking at a developmentally early stage. J Biol Rhythms. (2010) 25(6): 442-9.
  7. Yagita K et al., Development of the circadian oscillator during differentiation of mouse embryonic stem cells in vitro. Proc Natl Acad Sci U S A. (2010) 107(8): 3846-51.
  8. Guilding C et. al., Circadian oscillators in the epithalamus. Neuroscience. 2010 Sep 15;169(4):1630-9.
  9. Guilding C et. al., A riot of rhythms: neuronal and glial circadian oscillators in the mediobasal hypothalamus. Mol Brain. (2009) 2:28.
  10. Yoshii T et al., The neuropeptide pigment-dispersing factor adjusts period and phase of Drosophila''''s clock. J Neurosci. (2009) 29(8):2597-61.
  11. Akashi M et. al., Mitogen-activated protein kinase is a functional component of the autonomous circadian system in the suprachiasmatic nucleus. J Neurosci. (2008) 28(18): 4619-23.
  12. Dibner C et al., Circadian gene expression is resilient to large fluctuations in overall transcription rates. The EMBO Journal. (2008) 28(2): 123-134.
  13. Asai S et al., Single-cell imaging of c-fos expression in rat primary hippocampal cells using a luminescence microscope.
    Neuroscience Letters. (2008) 434(3) : 289-292.
  14. Ukai H et al., Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks. Nature Cell Biology. (2007) 9(11): 1327-34.
  15. Sato TK et al. Feedback repression is required for mammalian circadian clock function. Nature Genetics. (2006) 38: 312-319.


  1. Fluegge D et. al. Mitochondrial Ca2+ mobilization is a key element in olfactory signaling. Nat Neurosci. (2012)15(5): 754-62.
  2. Veitinger S et. al., Purinergic signalling mobilizes mitochondrial Ca2+ in mouse Sertoli cells. J Physiol. (2011) 589(Pt 21): 5033-55.


  1. Pratx G J et al., Radioluminescence Mircoscopy: Measuring the heterogeneous update of radiotracers in single living cells. PLoS One. (2012) 7(10): e46285.


  1. Hirsch J et al., A novel fry1 allele reveals the existence of a mutant phenotype unrelated to 5’->3’ exoribonuclease (XRN) activities in Arabidopsis thaliana roots. PLoS One. (2011) 6(2):e16724.

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